| Team members |
| Rank (within team) | User | Score | WU |
| 1 | Jens_Klausen | 466771 | 1034 |
| 2 | smASHer88_PS3 | 325290 | 1293 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | peterdiva | 151430 | 199 |
| 5 | Ugly | 140120 | 191 |
| 6 | RoXeD | 137390 | 562 |
| 7 | Lahm_Family_PS3 | 137105 | 472 |
| 8 | zoneur | 87603 | 199 |
| 9 | Jawgz | 57797 | 50 |
| 10 | smASHer88 | 57220 | 195 |
Congrats to Jens_Klausen who has now made the 1,000 Work Units Milestone!| Team members |
| Rank (within team) | User | Score | WU |
| 1 | Jens_Klausen | 443920 | 984 |
| 2 | smASHer88_PS3 | 321520 | 1280 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | peterdiva | 144390 | 193 |
| 5 | Ugly | 136020 | 177 |
| Team members |
| Rank (within team) | User | Score | WU |
| 1 | Jens_Klausen | 437200 | 970 |
| 2 | smASHer88_PS3 | 320384 | 1276 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | peterdiva | 143910 | 192 |
| 5 | RoXeD | 134080 | 551 |
| 6 | Ugly | 132660 | 172 |
| 7 | Lahm_Family_PS3 | 131785 | 452 |
| 8 | zoneur | 87603 | 199 |
| 9 | smASHer88 | 57220 | 195 |
| 10 | Jawgz | 55172 | 48 |
Aussie Rules Footy - 2,000,000 Points Milestone!| Grand Score | 2010545 (certificate) |
| Work Unit Count | 6444 (certificate) |
| Team Ranking (incl. aggregate) | 923 of 151286 |
Jawgz has now claimed the 50,000 Points Milestone!
Just before Christmas, on the December 22, 2008, Entrepreneur Jim Clark and current President of Stanford University - John Hennessy visited the offices of Vijay Pande and his Folding@Home team."Today, Dr. Clark along with John Hennessy (the President of Stanford University) visited our offices to hear about our recent work. They both were heavily involved in computer architecture in the past, so they were interested to hear about our work with GPUs and the success we are seeing there (in particular, the significant speed increases). Also, they are both interested in neuroscience and so I was excited to tell them about our recent Alzheimer's work.Anyway, I was excited to give them both an update and some idea of where we're going, and it was great fun for me to tell them all about how much we've done."
| Team members |
| Rank (within team) | User | Score | WU |
| 1 | Jens_Klausen | 393409 | 876 |
| 2 | smASHer88_PS3 | 313084 | 1252 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | RoXeD | 132100 | 543 |
| 5 | peterdiva | 130630 | 181 |
| 6 | Lahm_Family_PS3 | 124095 | 426 |
| 7 | Ugly | 114017 | 141 |
| 8 | zoneur | 87603 | 199 |
| 9 | smASHer88 | 56995 | 194 |
| 10 | Jawgz | 46094 | 43 |
Vijay Pande posted on his blog back on the 18th December, 2008 about a Possible New Alzheimer's Disease Drug to be made from new Folding@Home results. "On Tuesday, we presented our results regarding new possible drugs (small molecule leads) to fight Alzheimer's Disease at a recent meeting at Stanford. This meeting was part of the NIH Roadmap Nanomedicine center retreat and was supported by NIH grants to Folding@home.It's very early (so we are not publicly talking about the details until this has passed peer review), but we are very excited that it looks like we may have multiple small molecules which appear to inhibit toxicity of Abeta, the protein which is the toxic element in Alzheimer's Disease.This is exciting in many ways. It's been a long road for FAH to get to this point, but we are starting to see the possibility of seeing these results published easily before our 10th birthday (October 2010). Considering all the technology development that had to be done in the first five years, these results have come very quickly (in the last 3 years), which is exciting. In particular, we are now looking to apply these methods to other protein misfolding diseases (we have pilot projects for Huntington's Disease underway).Finally, I should stress that while we're very excited about this, it's still early and a lot can go wrong between where we are and having a drug that doctors can prescribe. Over the holidays, we will be double checking the experimental data, crossing t's and dotting i's to make sure there is nothing missed before we think about submitting this for peer reviewed publication. Also, there is still a long way from an interesting possible drug (where we are now) to something which has passed FDA clinical trials (where we'd love to be), and a lot can go wrong in clinical trials in particular.Thus, this is an important milestone for FAH and we are very grateful to all who have contributed."
It's 2009!!! I'd just like to wish everyone a Happy New Year!
Ugly has passed the 100,000 Points Milestone!Folding@Home's Statistics Server, used to provide all Team and Donor stats etc. will receive an update sometime in 2009 to speed up the time it takes to update the stats database, meaning that instead of waiting the first 45 minutes of each 2 hour update cycle just to see our Team stats page, it might only take the first 15 minutes, and hopefully with an hourly update cycle.An intention to update message is currently sitting beneath the lines above, telling us:Stats update in progress
External access to the Folding@home stats server is currently not available in order to expedite the stats input process. This was started on the hour and we expect this to take about 45 minutes. The stats updates run in 2 hour cycles.
"In 2009, we will be upgrading our stats server such that the whole database will fit in RAM (this used to be the case, but FAH has gotten quite big over the last few years and the related databases require over 20GB). We expect that this new stats server should greatly speed up stats updates."It's good to see that the Folding@Home team works to constantly improve their systems.
Vijay Pande has informed us of the Winter Holidays Schedule for Stanford University on his blog recently. SU will be closed until January 5, 2009, however Folding@Home will still be operating as always, but there is warning that should problems arise, the corresponding response will be slower than normal due to reduced staffing during the holidays."We'd like to wish all the FAH donors a happy holiday and thank all of you for all your great help with our project."
| Team members |
| Rank (within team) | User | Score | WU |
| 1 | Jens_Klausen | 343177 | 757 |
| 2 | smASHer88_PS3 | 307434 | 1235 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | RoXeD | 132100 | 543 |
| 5 | peterdiva | 116514 | 168 |
Ahhh, what a wonderful time of year! Staying up late on Christmas Eve, posting on my blog early Christmas morning! Can't wait to get stuck into my presents later today!Vijay has given us a heads up on his blog about some Scheduled Maintenance that is going to be performed over the Holidays period at Stanford University.
Our team, Aussie Rules Footy is now finally apart of the Top 1,000 Folding@Home teams.| Aussie Rules Footy |
| Date of last work unit | 2008-12-18 04:38:49 |
| Active CPUs within 50 days | 46 |
| Team Id | 52735 |
| Grand Score | 1724478 (certificate) |
| Work Unit Count | 5831 (certificate) |
| Team Ranking (incl. aggregate) | 998 of 149988 |
"As of today, Jens_Klausen now sits 2nd on the Team Leaderboard, with quite a stretch to reach my ol' faithful - smASHer88_PS3!!! No doubt this guy will chew through the 100k points buffer in no time, i'm just not looking forward to reporting on my own de-throning!"The writing was on the wall though in early November when Jens_Klausen added a 2nd GPU to his system:
"Future Team Leader, Jens_Klausen has recently added a second ASUS EN9600GT SILENT graphics card to his Computer, boosting his PPD (points per day) output even further!"Giving up the crown, my Playstation 3 - smASHer88_PS3 had held 1st spot since around February this year. After I started folding on Boxing Day 2007, I set out a goal of 300,000 points within 12 months (PS3's PPD = 900~1,000 x 365 days = 328,500~365,000 ... minus some gameplay and a bit of downtime here and there = 300,000 points). Lucky I compensated a bit, I only had 8 days spare! I'd also like to point out (cheekily) that by looking up Kakao Stats Update History for both smASHer88_PS3 and Jens_Klausen, I can say my PS3 snuck in the 300k points mark a couple of hours before Jens_Klausen! Haha, some small consolation that is!
| Team members |
| Rank (within team) | User | Score | WU |
| 1 | Jens_Klausen | 301541 | 656 |
| 2 | smASHer88_PS3 | 300615 | 1212 |
Our latest member to conquer the 100,000 points milestone - peterdiva!Vijay Pande has posted on his blog a very important notice about an update to the Folding@Home End User License Agreement (EULA)."We added the word "written" to this sentence:"You may use this software on a computer system only if you own the system or have the written permission of the owner."
We felt that this was an important addition in order to avoid any confusion. There have been a few situations where donors felt that they had permission, but the owners of the computers did not. Having written permission is the best way to make sure that there is no doubt. It also gives protection to the donor in that he/she would then have proof of permission, avoiding problems involving oral agreements."
I'd like to re-affirm that you could find yourself in a situation of getting sued for installing and running this program unauthorised, as many people have gotten into trouble setting up multiple computers at they're place of work (such as a school I.T. Administrator setting up tens to hundreds of computers) when they weren't authorised to do so, and have in some cases been ordered to pay damages for things such as increases in power bills, internet bills etc. Also, not having sufficient knowledge about the program and how it can affect different computers etc. (such as Notebooks being advised to run at no more than 90% CPU usage due to their less than optimal cooling systems) can lead to a bit of a blame game as far as what caused the computer to pack itself in and who is going to pay for it!
So guys, make sure you get written consent to run Folding@Home on computers or machines that are not your own. And be sure to inform those owners or bill-payers of the potential to have slightly higher power and internet bills whilst running this program (not a big deal for one or two machines, but any more, the extra power and internet usage quickly adds up!). Providing you do the right thing by the owner, i'm sure they will enjoy helping out a Distributed Computing Project such as Folding@Home.
Vijay Pande's blog yet again brings good news with yet another Paper being published, this time about the Playstation 3 Folding@Home client - Accelerating Molecular Dynamic Simulation on the Cell processor and PlayStation 3.
The abstract reads: "Implementation of molecular dynamics (MD) calculations on novel architectures will vastly increase its power to calculate the physical properties of complex systems. Herein, we detail algorithmic advances developed to accelerate MD simulations on the Cell processor, a commodity processor found in PlayStation 3 (PS3). In particular, we discuss issues regarding memory access versus computation and the types of calculations which are best suited for streaming processors such as the Cell, focusing on implicit solvation models. We conclude with a comparison of improved performance on the PS3's Cell processor over more traditional processors."Papers of this type not only help the Folding@Home team at Stanford, but can potentially help many others outside of the Project. Whether it helps out others involved in the field of Molecular Dynamics, or people that intend to use and program for the CELL processor, knowledge gained can be knowledge shared!
Only on Tuesday Vijay Pande announced on his blog that the Project published New Alzheimer's Disease Work. Now another paper, Folding@Home's 59th to be exact, has been published - 'Side-chain recognition and gating in the ribosome exit tunnel'."The ribosome is a fascinating molecular machine, responsible for the synthesis of proteins. For this reason it is of fundamental importance to protein folding (as the last step in the central dogma of biology) as well as to human health (since the ribosome is the target of a very large fraction of antibiotics)."Vijay mentions that this paper has been made possible by the contributions of folders running 'bigWU' enabled classic clients stating:
"the ribosome is so huge that it would not run on regular classic clients."It's certainly good to see a couple more important research papers come out lately, and only a day after another! I can't wait to see what other papers get released and how they can help us move forward in the Protein research field.
My 2nd Playstation 3 - Lahm_Family_PS3 is the 5th team member to achieve the 100,000 points milestone! Thus moving up a category in the Major Milestone Club.| Team members |
| Rank (within team) | User | Score | WU |
| 1 | smASHer88_PS3 | 293785 | 1189 |
| 2 | Jens_Klausen | 265299 | 569 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | RoXeD | 132100 | 543 |
| 5 | Lahm_Family_PS3 | 100383 | 343 |
| 6 | peterdiva | 94067 | 152 |
| 7 | Ugly | 66590 | 69 |
| 8 | zoneur | 65715 | 145 |
| 9 | smASHer88 | 56240 | 193 |
| 10 | BulleenAnt1 | 42574 | 145 |
The latest news from Vijay Pande's blog is about the publication of a key paper relating to Alzheimer's Disease - 'Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach'."I am very happy to announce that a first key work from the Folding@home project on Alzheimer's Disease (AD) was just published"
"In many ways, this paper is the "tip of the iceberg" for the Folding@home activities in AD, with a lot more interesting results to come, especially in terms of experimental tests of our predictions and interesting new possibilities for new drugs and AD therapeutics. So, while we're excited that this result is now past peer review, we're even more excited for what's coming down the pipeline, waiting peer review. We'll keep you posted as more results become public, hopefully with some even bigger announcements in 2009."Hopefully this will mean Folding@Home as a Project will start to see some real fruit for all it's labour!
"It was asked which clients participated. This work started several years ago and took some time to analyze and then publish. So, it ran exclusively on classic clients. For the follow up simulations, we are using a mixture of GPU, SMP, and classic clients. Due to the large number of classic clients, they allow us to calculations not possible on the other platforms. However, the raw speed (but smaller number) of the GPU and SMP clients allow us to get a good rough idea quickly, refining later with classic clients."
| Team members |
| Rank (within team) | User | Score | WU |
| 1 | smASHer88_PS3 | 290635 | 1178 |
| 2 | Jens_Klausen | 251679 | 538 |
| 3 | Ravenge5 | 166003 | 745 |
| 4 | RoXeD | 132100 | 543 |
| 5 | Lahm_Family_PS3 | 97053 | 333 |
| 6 | peterdiva | 89374 | 132 |
| 7 | zoneur | 65715 | 145 |
| 8 | Ugly | 57770 | 54 |
| 9 | smASHer88 | 55491 | 192 |
| 10 | BulleenAnt1 | 42445 | 144 |
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